ea0025p116 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011
Shearer Kirsty
, Stoney Patrick
, Ransom Jemma
, Helfer Gisela
, Ross Sandy
, Morgan Peter
, McCaffery Peter
Tanycytes line the wall of the third ventricle sitting at the boundary between the cerebral spinal fluid (CSF) and the hypothalamus. Tanycytes actively take up substances from the CSF using their villi-like apical projections that extend into the third ventricle. Retinol is one such compound and can be oxidized by these cells to retinoic acid, which can be released to regulate transcription in the hypothalamus via specific nuclear receptors. Two retinal dehydrogenases (RALDHs)...